Chemical Feasibility Studies Concerning Potential Prodrugs of Acetylsalicylic Acid.

Acetylsalicylic acid as a potential pediatric health hazard: legislative aspects concerning accidental intoxications in the European Union

Acetylsalicylic acid is a frequently used medication worldwide. It is not used in pediatrics due its association with Reye syndrome. However, in case of pediatric intoxication, children are more fragile to salicylate poisoning because of their reduced ability of buffer the acid stress. Intoxication leads to a decoupling of oxidative phosphorylation and subsequently to a loss in mitochondrial fu...

Feasibility of laboratory studies concerning life on Venus.

F E W SCIENTISTS unequivocally maintain that life can exist on Venus. 6,11,2~ In fact, several authors have questioned the plausibility of life or, that planet. 1,x~,ls,2~ Impending manned space voyages increase the importance of conducting investigations into the possibility of life existing there, provided that such studies are indeed feasible and likely to produce information of value. Unfor...

Studies concerning the Production of Lactobacilli Acid in Lactobacillus Plantarum

Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine.

One of the main obstacles for cancer therapies is to deliver medicines effectively to target sites. Since stroma cells are developed around tumors, chemotherapeutic agents have to go through stroma cells in order to reach tumors. As a method to improve drug delivery to the tumor site, a prodrug approach for gemcitabine was adopted. Amino acid and dipeptide monoester prodrugs of gemcitabine were...

Electrochemical Sensors for Detection of Acetylsalicylic Acid

Acetylsalicylic acid (AcSA), or aspirin, was introduced in the late 1890s and has been used to treat a variety of inflammatory conditions. The aim of this work was to suggest electrochemical sensor for acetylsalicylic detection. Primarily, we utilized square wave voltammetry (SWV) using both carbon paste electrode (CPE) and of graphite pencil electrode (GPE) as working ones to indirect determin...